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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described by their focus on practical aspects of study design that include recruitment and consent, adherence and the use routinely available equipment.

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A practical trial that employs various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for practical trials to be valid, and 프라그마틱 정품 확인법 it also helps reduce bias in the results. However, too much heterogeneity can result in problems with the design of the trial.

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The goal of pragmatic trials is to mimic real-life scenarios and 프라그마틱 슬롯 체험 to achieve maximum credibility externally. They are usually ordered by policymakers and practitioners in order to inform their decisions. They can also be a great method to determine the causality between an intervention and its outcomes. They should, however, not, be used to replace the need for explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a practical trial that include the recruitment process, the design and delivery of the intervention, and monitoring.

The number of pragmatic trials is growing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), 프라그마틱 무료체험 메타 returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.