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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and included participants from different geographic areas. This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity, and it also helps reduce the chance of bias in the results. However, too much heterogeneity, can cause problems with the design of the trial.

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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually ordered by policymakers and practitioners in order to inform their decisions. They can also be a great method to determine the causality between an intervention and its results. However, they shouldn't be used as a substitute for explanatory studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should be used to replace explanation tests or 프라그마틱 슬롯 무료체험 if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm a physiological or clinical hypothesis and pragmatic trials that inform the policy and practice of. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool attempted to define the elements of a pragmatic trial that include the recruitment process, the design and implementation of the intervention, as well as monitoring.

The number of pragmatic trials is growing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these trials were conducted in primary care settings.